One of the most important indicators reflecting the level of development of innovative activity in the state is the volume of innovative goods produced in the country. At the same time it is important to take into account regional aspects, especially in connection with the recently growing role of regions as sources of innovative changes. Therefore the focus of this study is the regional differentiation of the proportion of innovative goods, works, services in the total volume of goods shipped, work and services performed, considered for the period of 2016-2018. As measures of the level of differentiation of the analyzed indicator the absolute and relative range of variation, variance, standard deviation and coefficient of variation are calculated. It was revealed that the uneven production of innovative goods, work, services in the Russian Federation is high and it increased during the analyzed period.